2021 IARS Mentored Research Award

2021 IMRA Award Winner Kendall SmithKendall Smith, MD, PhD
Assistant Professor
Washington University in St. Louis
St. Louis, MO

Dr. Smith’s Research

Role of Transcriptomic Circadian Rhythms in Postoperative Delirium

Delirium is a potentially preventable disorder characterized by transient fluctuating disturbances in attention, consciousness, and cognition. It is a common complication in older adults following major surgery under general anesthesia and is associated with poor postoperative trajectories with costs upwards of $32 billion annually. Circadian rhythm disruptions are thought to contribute to adverse perioperative outcomes including postoperative delirium, but little is known about their perioperative trajectories at the molecular level. The objective of this proposal is to characterize transcriptomic circadian rhythm changes across the perioperative continuum and to elucidate their relationship to postoperative delirium. We will utilize an externally validated transcriptomic algorithm to directly measure internal circadian phase across the perioperative continuum. We hypothesize that changes will be observed in internal circadian phase following the acute event of general anesthesia and major cardiac surgery. Furthermore, we anticipate that the degree of these changes will be associated with postoperative delirium severity, as measured by serial Confusion Assessment Method (CAM) assessments. The significance of this work is two-fold: First, it would provide the first transcriptomic characterization of circadian rhythms during the perioperative period for future therapeutics. Second, it would allow for the discovery of biomarkers that may predict clinical trajectories leading to better outcomes in this vulnerable patient population.

Encourage, stimulate, and fund ongoing anesthesia-related research projects that will enhance and advance the specialty, and to disseminate current, state-of-the-art, basic and clinical research data in all areas of clinical anesthesia, including perioperative medicine, critical care, and pain management. The IARS is focused solely on the advancement and support of education and scientific research related to anesthesiology.

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IMRA Awards

This award is intended to support investigations that will further the understanding of clinical practice in anesthesiology and related sciences. Up to four research projects are selected annually, with a maximum award of $175,000 each, payable over two years.

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