2008 Clinical Scholar Research Award

Konrad Meissner, MD
Instructor, Department of Anesthesiology
Washington University in St. Louis
St. Louis, Missouri

Dr. Meissner’s Research

Role of P-glycoprotein in Cerebral Morphine Disposition and Analgesia.

Related Publications

Cyclosporine-inhibitable Cerebral Drug Transport Does Not Influence Clinical Methadone Pharmacodynamics.
Meissner K, Blood J, Francis AM, Yermolenka V, Kharasch ED.

Interindividual variability and drug interaction studies suggest that blood-brain barrier drug transporters mediate human methadone brain biodistribution. In vitro and animal studies suggest that methadone is a substrate for the efflux transporter P-glycoprotein, and that P-glycoprotein-mediated transport influences brain access…

Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics.
Meissner K, Avram MJ, Yermolenka V, Francis AM, Blood J, Kharasch ED.

The blood-brain barrier is richly populated by active influx and efflux transporters influencing brain drug concentrations. Morphine, a drug with delayed clinical onset, is a substrate for the efflux transporter P-glycoprotein…

Read Dr. Meissner’s recent publications and articles.