2007 Clinical Scholar Research Award

Dr. Hahnenkamp’s Research

Perioperative protective effects of lidocaine – Clinical study on the route and timing of administration

Related Publications

Time-dependent modulation of muscarinic m1/m3 receptor signalling by local anaesthetics.
Picardi S, Stevens MF, Hahnenkamp K, Durieux ME, Lirk P, Hollmann MW.

Signalling of several G-protein-coupled receptors of the Gq/11 family is time-dependently inhibited by local anaesthetics (LAs). Since LA-induced modulation of muscarinic m1 and m3 receptor function may explain their beneficial effects…

Lidocaine reduces neutrophil recruitment by abolishing chemokine-induced arrest and transendothelial migration in septic patients.
Berger C, Rossaint J, Van Aken H, Westphal M, Hahnenkamp K, Zarbock A.

The inappropriate activation, positioning, and recruitment of leukocytes are implicated in the pathogenesis of multiple organ failure in sepsis. Although the local anesthetic lidocaine modulates inflammatory processes, the effects of lidocaine in sepsis…

Local anesthetic-induced inhibition of human neutrophil priming: the influence of structure, lipophilicity, and charge.
Picardi S, Cartellieri S, Groves D, Hahnenkamp K, Gerner P, Durieux ME, Stevens MF, Lirk P, Hollmann MW.

Local anesthetics (LAs) are widely known for inhibition of voltage-gated sodium channels underlying their antiarrhythmic and antinociceptive effects. However, LAs have significant immunomodulatory properties and were shown to affect human neutrophil functions…

Read Dr. Hahnenkamp’s recent publications and articles.