2010 SCA-IARS Mid-Career Grant and 2007 SCA Starter Grant

Dr. Hare’s Research

Determining the hemoglobin threshold for hypoxic cellular responses: Studies in anemic hypoxia inducible factor (HIF)-ODD-luciferase mice.

The Threshold Hematocrit for Cerebral Hypoxia is Maintained by Protective Cardiovascular Mechanisms: The Role for Neuronal Nitric Oxide Synthase (nNOS).

Dr. Hare has a clinical focus in blood conservation, as well as defining adaptive and maladaptive cerebral and cardiovascular regulatory mechanisms in experimental models of acute hemodilution.

Related Publications

Transfusion Triggers for Guiding RBC Transfusion for Cardiovascular Surgery: A Systematic Review and Meta-Analysis.
Curley GF, Shehata N, Mazer CD, Hare GM, Friedrich JO..

Restrictive red cell transfusion is recommended to minimize risk associated with exposure to allogeneic blood. However, perioperative anemia is an independent risk factor for adverse outcomes after cardiovascular surgery. The purpose of this systematic review and meta-analysis is to determine whether perioperative restrictive transfusion thresholds are associated with inferior clinical outcomes in randomized trials of cardiovascular surgery patients.

Anesthetic approach to high-risk patients and prolonged awake craniotomy using dexmedetomidine and scalp block.
Garavaglia MM1, Das S, Cusimano MD, Crescini C, Mazer CD, Hare GM, Rigamonti A.

Awake craniotomy with intraoperative speech or motor testing is relatively contraindicated in cases requiring prolonged operative times and in patients with severe medical comorbidities including anxiety, anticipated difficult airway, obesity, large tumors, and intracranial hypertension. The anesthetic management of neurosurgical patients who possess these contraindications but would be optimally treated by an awake procedure remains unclear.