2016 IARS Mentored Research Award $150,000

Eric Vu, MD
Anesthesiology Resident
Baylor College of Medicine
Houston, Texas

Dr. Vu’s Research

Predictive Analytic Tool for Diagnosis of Coronary Allograft Vasculopathy

The objective of this project is to develop and study a new predictive algorithm for pediatric transplant associated coronary allograft vasculopathy (CAV), an immunologic phenomenon affecting 50% of patients 5-15 years after orthotopic heart transplants. Diagnosis of disease remains difficult due to nonspecific symptomatology, and many patients are subjected to the increased morbidity and mortality of numerous cardiac catheterizations and exposure to anesthesia when disease is suspected. To improve diagnosis, the performance of a novel electrocardiogram (ECG) algorithm in distinguishing CAV will be retrospectively tested in patients undergoing cardiac catheterization after heart transplantation. The algorithm has the capability of measuring dynamic ST segment changes of a reconstructed 3-dimensional ST segment vector from standard 5 lead ECG in real-time. In addition, biomarker panel testing utilizing markers of inflammation and myocyte injury will be performed to establish a multivariate model to improve the predictive power in CAV diagnosis. Finally, utilizing discrete laboratory and real time physiologic variables obtained in the cardiac catheterization lab (heart rate, heart rate variability, ST instability), a predictive analytic algorithm will be developed as a risk-assessment tool for CAV in comparison to the current gold standard of diagnosis, angiography. Because CAV remains one of the leading causes of morbidity after pediatric orthotopic heart transplantation, a predictive analytic tool will aid in the earlier diagnosis of this critical disease, and in the future may guide therapies, such as medical management, revascularization, and alert the need for retransplantation.

Encourage, stimulate, and fund ongoing anesthesia-related research projects that will enhance and advance the specialty, and to disseminate current, state-of-the-art, basic and clinical research data in all areas of clinical anesthesia, including perioperative medicine, critical care, and pain management. The IARS is focused solely on the advancement and support of education and scientific research related to anesthesiology.

A&A Case Reports

IMRA Awards

This award is intended to support investigations that will further the understanding of clinical practice in anesthesiology and related sciences. Up to four research projects are selected annually, with a maximum award of $175,000 each, payable over two years.

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