Higher versus Lower Dose Corticosteroids for Severe to Critical COVID-19: A Systematic Review and Dose-Response Meta-analysis. 11/30/22. Pitre T. Ann Am Thorac Soc.
According to this article, compared to lower-dose corticosteroids (6mg/day*10), higher-dose corticosteroids (12 mg/day*10) probably reduce mortality, and may reduce mechanical ventilation. Clinicians and guideline developers should consider benefits of treatment with higher doses of corticosteroids. The ongoing RECOVERY trial will compare high-dose dexamethasone (20 mg/day*5 followed by 10mg/day*5) with the usual treatment of low-dose dexamethasone (6 mg/day*10) and may provide necessary information to support an appropriately timed and increased dose.
View more information about the RECOVERY trial.
https://www.atsjournals.org/doi/10.1513/AnnalsATS.202208-720OC
The material on this website is provided for informational purposes and does not constitute medical advice. New knowledge is added daily and may change over time. Opinions expressed should not be construed as representing IARS policy or recommendations. References and links to third parties do not constitute an endorsement or warranty by IARS.
International Anesthesia Research Society
GuideStar/Candid