Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-Cov-2 Infection. 12/12/22. Kwan AC. Nature Cardiovascular Research.
Postural orthostatic tachycardia syndrome (POTS) has been previously described after COVID-19 infection. Here, the authors describe the relation of POTS to COVID-19 vaccination reviewing medical records from a cohort of 284,592 COVID-19-vaccinated individuals and comparing the odds of a new POTS diagnosis 90_days after vaccine exposure to those 90_days before exposure. A POTS diagnosis was more frequent after vaccination (O.R. 1.52) with an absolute increase of slightly less than 0.1% (0.18% to 0.27%). A similar comparison was made for the occurrence of POTS before and after COVID-19 infection in a group of 12,460 individuals with proven infection. The post-infection risk of a new diagnosis of POTS was significantly higher after infection than after vaccination (O.R. 5.35). POTS occurred much less frequently than myocarditis after vaccination but more frequently than myocarditis after infection.
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