2018 Kosaka Best of Meeting Abstract Award Finalists and Winners

IARS 2018 Annual Meeting and International Science Symposium

Improving Health Through Discovery and Education
April 27-May 1 • Chicago, IL

These 30 abstract authors were selected from more than 600 abstract author submissions to the IARS 2018 Annual Meeting and International Science Symposium for the distinction of the Kosaka Best of Meeting Award.

The top 30 abstract authors submitted in Clinical Research, Basic Science or by a scholar displayed their posters for viewing and discussion during the Kosaka Best of Meeting Abstract Awards Session, Sunday April 28. The top 9 finalists (3 from Clinical Research, 3 from Basic Science, and 3 authors who are scholars) presented their original research orally during this session. These top 9 finalists also competed for the top award in their category and a $500 prize.

*Clinical Research-Winner*
Neuroscience in Anesthesiology and Perioperative Medicine
1393. Optical Neuromonitoring Detects Brain Hypoxia
David R. Busch1, Wesley B. Baker2, Wensheng Guo2, Lian He3, Mamadou Diop4, Daniel Milej4, Venkaiah Kavuri3, Olivia Amendolia3, Ramani Balu3, Keith St. Lawrence4, Arjun G. Yodh3, William A. Kofke5
1University of Texas Southwestern, Dallas, TX, 2Children’s Hospital of Philadelphia, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, PA, 4University of Western Ontario, London, Ontario, Canada, 5Hospital of the University of Pennsylvania, Philadelphia, PA

*Basic Science Research-Winner*
Pain Mechanisms
955. GABA neurons in the rostromedial tegmental nucleus modulate analgesia in mice
Norman E. Taylor1, Hu Long2, JunZhu Pei3, Phanidhar Kukutla1, Ksenia Y. Vlasov3, Ken Solt4, Gary J. Brenner4
1Massachusetts General Hospital, Boston, MA, 2West China Hospital of Stomatology, Chengdu, China, 3Massachusetts Institute of Technology, Cambridge, MA, 4Harvard Medical School, Boston, MA

*Scholars Abstracts-Winner*
Neuroscience in Anesthesiology and Perioperative Medicine
953. Power Spectrum and Frontal Alpha Band Activity Saturation Predicts Loss of Response to Verbal Command in Older Adults during Anesthetic Induction with Propofol: A Diagnostic Test Approach
Carlos M. Fuentes, Juan C. Pedemonte, Andrea Sanchez, Martin Irani, Mohit Rana, Victor Contreras, Ignacio Cortinez
Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile

Clinical Research-Top Finalists

Ambulatory Anesthesia
1256. Finding the Body Mass Index Threshold for Selection of Patients for Ambulatory Open Hernia Repair
Eric Rosero, Girish Joshi
UT Southwestern Medical Center, Dallas, TX

Pediatric Anesthesiology
1099. Intraoperative intravenous infusion of lidocaine for better postoperative analgesia in children undergoing laparoscopic hernia repair
Ji-Min Lee1, Jeongrim Lee2
1Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, 2Yonsei University College of Medicine, Seoul, Korea

Basic Science Research-Top Finalists

Anesthetic Pharmacology
1410. Identification of a modulatory site of action for the volatile anesthetic isoflurane in TREK1 tandem pore potassium channels
Paul M. Riegelhaupt1, Kellie Woll2, Thomas T. Joseph2, Kiran A. Vaidya1, Crina M. Nimigean1, Roderic G. Eckenhoff2
1Weill Cornell Medicine, New York, NY, 2University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Neuroscience in Anesthesiology and Perioperative Medicine
1388. Activation of Mouse Orexin Neurons Facilitates Anesthesia Emergence and Increases Pain tolerance
Wei Zhou, Kevin Cheung, Zhonghui Guan, Philip A. Kurien, Lily Jan, Lynn Wang
University of California, San Francisco, San Francisco, CA

Scholars Abstracts-Top Finalists

Geriatric Anesthesia
823. Considerations for Scoring the Clock Drawing Test for Impairment of Geriatric Patients in the Perioperative Setting: A Comparison of Three Common Scoring Criteria
Mitchel Y. Zhang, Bailey Frei, Kristen Woodward, Shawna Amini, Patrick J. Tighe, Chris Giordano, Catherine Price
University of Florida, Gainesville, FL

Neuroscience in Anesthesiology and Perioperative Medicine
928. Midazolam Sedation during the Periodic Experience of Pain Decreases Functional Connectivity Both within and between Brain Systems for Pain Processing and Memory Encoding
Christopher T. Smith, Keith M. Vogt, James W. Ibinson
University of Pittsburgh, Pittsburgh, PA

Clinical Research-Finalists

Ambulatory Anesthesia
777. Is There a Threshold Age to Select Patients for Ambulatory Abdominal Surgery?
Eric Rosero, Girish Joshi
UT Southwestern Medical Center, Dallas, TX

Anesthetic Pharmacology
1429. Coagulation effect of sugammadex using thromboelastography in a randomized controlled study of surgical patients
Hae Wone Chang, Il Ok Lee, Byung Gun Lim
Korea University Guro Hospital, Seoul, Korea

Blood Management
1348. Factor IX from Prothrombin Complex Concentrate Augments Low Tissue Factor-triggered Thrombin Generation: An Exploratory In Vitro Study
Ezeldeen Abuelkasem1, Shaheer Shaheer Hasan2, Brittney Williams2, Reney Handerson2, Michael A. Mazzeffi2, Kenichi Tanaka2
1University of Pittsburgh Medical Center, Pittsburgh , PA, 2University of Maryland School of Medicine, Baltimore, MD

Economics, Education and Policy
747. Effect of Night Float on Anesthesiology Resident Sleep Patterns: An Observational Study
Lauren K. Dunn, Amanda Kleiman, Katherine Forkin, Mark S. Quigg, Allison J. Bechtel, Julie L. Huffmyer, Edward C. Nemergut
University of Virginia, Charlottesville, VA

984. The Role of Gender and Body Language on Patient Perception of Physicians
Katherine Forkin, Lauren K. Dunn, Allison J. Bechtel, Amanda Kleiman, Jennifer F. Potter, Julie L. Huffmyer, Edward C. Nemergut
University of Virginia, Charlottesville, VA

Neuroscience in Anesthesiology and Perioperative Medicine
695. Non-invasive Optical Quantification of Absolute Cerebral Blood Flow in Adults: Validation against MRI
Daniel Milej2, Wesley B. Baker1, Lian He1, Mamadou Diop2, Ramani Balu1, John A. Detre1, Arjun G Yodh1, Keith St. Lawrence2, Androu Abdalalak2, Sudipto Dolui1, Udunna Anazodo2, Venkaiah Kavuri1, William Pavlosky2, Olivia Amendolia1, Francis Quattrone1, Andrew W. Kofke1
1University of Pennsylvania, Philadelphia, PA, 2University of Western Ontario, London, Ontario, Canada

Perioperative Anesthesia
555: Association of Preoperative Anticholinergic Medication Exposure with Postoperative Healthcare Resource Use and Outcomes: A Population-based Cohort Study
Deric B. Diep1, Coralie Wong2, Carl van Walraven1, Daniel I McIsaac1
1University of Ottawa, Ottawa, Canada, 2The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Basic Science Research-Finalists

Blood Management
838. Contrasting Effects of Stored Allogeneic Red Blood Cells and Their Supernatants on Permeability and Inflammatory Responses by Human Pulmonary Artery Endothelial Cells
Junghyun Kim, Trang Nguyen, Michael A. Mazzeffi, Kenichi Tanaka, Anna Birukova, Konstantin Birukov
University of Maryland, Baltimore, Baltimore, MD

Critical Care
702. Role of Toll-like Receptor Signaling in Sepsis-induced Coagulopathy in Mice
Brittney Williams, Ping Cui, Olivia Conn, Kenichi Tanaka, Lin Zou, Wei Chao
University of Maryland Baltimore, Baltimore, MD

Neuroscience in Anesthesiology and Perioperative Medicine
1039. Adolescent rats display long-lasting abnormalities in REM sleep quantity and structure after postnatal anesthesia
Nadia Lunardi, Ryan Sica, Navya Atluri, Zhiyi E. Zuo
University of Virginia School of Medicine, Charlottesville, VA

621. Neonatal Disruption of PSD-95 PDZ Domain-mediated Protein-protein Interactions Alters Dendritic Spine Morphology, Long-term Potentiation, and Causes Deficits in Learning and Memory in Mice
Michele L. Schaefer, Meina Wang, Patric Perez, Jing Xu, Reilley P. Mathena, Roger A. Johns
Johns Hopkins University School of Medicine, Baltimore, MD

940. Preliminary Evidence of Neural Inertia in Human Subjects undergoing Xenon Anesthesia
Charles W. Carspecken, Andrew McKinstry-Wu, Alexander Proekt, Max B. Kelz
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Perioperative Anesthesia
1417. General Anesthesia Alters Gut Microbiota Diversity and Composition in Mice
Mara A. Serbanescu1, Reilley P. Mathena1, Raul Cano2, Tasha Santiago-Rodriguez2, Theresa Hartsell1, Cyrus D. Mintz1
1Johns Hopkins School of Medicine, Baltimore, MD, 2Institute for Life Science Entrepreneurship, Union, NJ

1141: Histone Subunits Disrupt Lung Vascular Endothelial Cell Barrier in Trauma
Seakwoo Lee, Ramasubramanian Baalachandran, Trang Nguyen, Yunbo Ke, Anna Birukova, Kenichi Tanaka, Konstantin Birukov
University of Maryland School of Medicine, Baltimore, MD

Scholars Abstracts-Finalists

Anesthetic Pharmacology
1101. The effects of dexmedetomidine on hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in mouse thalamocortical neurons
Catharina Westphal, Stefan Schwerin, Claudia Kopp, Gerhard Schneider, Stephan A. Kratzer, Rainer Haseneder
Klinikum rechts der Isar TU Munich, Munich, Germany

Cardiovascular Anesthesiology
814. Energetic performance index improvement after Glenn and Damus-Kaye-Stansel procedure using vector flow mapping analysis
Atsushi Kainuma1, Kazuma Hayase1, Koichi Akiyama2, Yoshifumi Naito1, Masaru Shimizu1, Keiichi Itatani1, Teiji Sawa1
1Kyoto Prefectural University of Medicine, Kyoto, Japan, 2Columbia University, New York, NY

Neuroscience in Anesthesiology and Perioperative Medicine
1413. Cognitive Associates of the Digital Clock Drawing Test in Older Adults: Total Clock Time and Pre-first Hand Latency
Catherine Dion1, Franchesca Arias1, Cheshire Hardcastle1, Shawna Amini1, Randall Davis2, Patrick J. Tighe1, Catherine Price1
1University of Florida, Gainesville, FL, 2MIT, Cambridge, MA

646: Measuring Post-Operative Cognitive Dysfunction in Older Adults using the Dalhousie Computerized Attention Battery
Yaeesh Sardiwalla, Gail Eskes, Ronald B George, Michael Schmidt
Dalhousie University, Halifax, Nova Scotia, Canada

1057. Perioperative Trajectory of Alzheimer’s Disease Biomarkers in Surgical Patients and Matched Non-surgical Controls
Yee Ching Vanessa Cheong1, Mary Cooter2, Richard L. Huang3, Heather E. Whitson2, Harvey J. Cohen2, Joseph P. Mathew2, Miles Berger2
1Duke-NUS Medical School, Singapore, Singapore, 2Duke University Medical Center, Durham, NC, 3Duke University, Durham, NC

Obstetric Anesthesiology
753. Transcutaneous P6 acupoint electrical stimulation prevents both nausea and vomiting during elective cesarean section under combined spinal-epidural: a randomized control clinical trial
Danielle Levin, Shaul Cohen, Scott Mellender, Adil Mohiuddin, Rong Zhao, Geza Kiss, Enrique Pantin
Rutgers – Robert Wood Johnson Medical School, New Brunswick, NJ

Technology, Computing and Simulation, Equipment Monitoring
795. Diagnostic Accuracy of Point-of-care Gastric Ultrasound: A Bayesian Analysis
Luis E. Chaparro1, Richelle Kruisselbrink1, Angineh Gharapetian1, Noam Ami2, Dustin Richler2, Vincent W. Chan1,2, Anahi Perlas2
1University of Toronto, Toronto, Ontario, Canada, 2Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada