2017 Kosaka Best of Meeting Abstract Award Finalists and Winners

IARS 2017 Annual Meeting and International Science Symposium

Improving Health Through Discovery and Education
Ma 6–9, 2017 • Washington, DC

These 30 abstract authors were selected from more than 600 abstract author submissions to the IARS 2017 Annual Meeting and International Science Symposium for the distinction of Kosaka Best of Meeting Awards Finalists.

From these 30 abstract authors, 9 top finalists in Clinical Research, Basic Science Research and Scholars Abstracts were invited to present their research to a panel of judges to compete for top category honors at the Kosaka Best of Meeting Abstract Awards Session that took place on Sunday, May 7, 2017, 11:00 am – 1:00 pm.

*Clinical Research Award Winner*
Geriatric Anesthesia
GA 74 (1596): Persistent Pain is Associated with Accelerated Memory Decline and Dementia in a Longitudinal Cohort of Elders
Elizabeth L Whitlock, MD, MSc, L. G. Diaz-Ramirez, MS, M. M. Glymour, ScD, MS, W. J. Boscardin, PhD, Kenneth E. Covinsky, MD, Alexander K. Smith, MD, MPH
University of California, San Francisco School of Medicine, San Francisco, California

*Basic Science Research Award Winner*
Anesthetic Pharmacology
AP 6 (1785): High Throughput Screening for Novel General Anesthetics in Larval Zebrafish
Xiaoxuan Yang, MD¹, Youssef Jounaidi, PhD², Jennifer Dai, PhD, MS², Francisco Marte, BA², Renee V. Daigle, PhD², Stuart Forman, MD, PhD^2
1Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

*Scholars Award Winner*
Sleep Medicine
SM 16 (1404): Using DVPRS as a Single-Item Screening Tool for Postoperative Sleep Disturbance
Albert Hsu, MD, Christian Calilung, MSc, Winifred Rojas, BSN, RN, CCRP, Krista Highland, PhD, Chester Buckenmaier, MD, Michael Kent, MD
Walter Reed National Military Medical Center, Bethesda, Maryland

Top Finalists — Clinical Research

Airway Management
AM 37 (1784): Peak Cervical Spinal Cord Strain Predictions are Affected by the Point of Force Application during Direct Laryngoscopy
Benjamin C. Gadomski, PhD¹, Brad J. Hindman, MD², Brandon G. Santoni, PhD³, Michael Todd, MD⁴, Vincent C. Traynelis, MD⁵, Ricardo B. Fontes, MD, PhD⁵, Christian M. Puttlitz, PhD^1
1Colorado State University, Fort Collins, Colorado, ²University of Iowa, Iowa City, Iowa, ³Foundation for Orthopaedic Research and Education, Tampa, Florida, ⁴University of Minnesota, Minneapolis, Minnesota, ⁵Rush University, Chicago, Illinois

Pediatric Anesthesiology
PED 27 (1989): Virtual Reality for Educating and Reducing Preoperative Anxiety in Children, Phase 1: Design, Face Validity and Acceptability by Health Care Professionals
Benjamin J. O’Sullivan, MBChB¹, Katie Brezel, BScN¹, Monica Caldera, BScN^{1, Maria Salman, MD1, Fahad Alam, MD, FRCPC2, Clyde Matava, MD1
1}The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada, ²Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Top Finalists — Basic Science Research

Neuroscience in Anesthesiology and Perioperative Medicine
NR 37 (2058): Ketamine Reduces Post-Traumatic Brain Injury Neurogenesis and Improves Outcomes in Mice
Austin Peters, MD, Laura E. Villasana, PhD, Eric Schnell, MD, PhD
Oregon Health & Science University, Portland, Oregon

Neuroscience in Anesthesiology and Perioperative Medicine
NR 37 (1794): GABA Neurons in the Rostromedial Tegmental Nucleus Modulate Arousal and Anesthetic Sensitivity in Mice
Ksenia Y. Vlasov, BA², JunZhu Pei, BS², Norman E. Taylor, MD, PhD¹, Christa J. Van Dort, PhD¹, Jennifer A. Guidera, BA¹, Emery N. Brown, MD, PhD¹, Ken Solt, MD^1
1Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, ²Massachusetts Institute of Technology, Cambridge, Massachusetts

Top Finalists — Scholars

Perioperative Anesthesiology
PA 35 (1124): Postoperative Pulmonary Complications Not Increased With Combined Regional + General Anesthesia Compared to General Anesthesia Alone: A Sub-Analysis of the Perioperative Research Network Study
Kristina Coger, MD¹, Gyorgy Frendl, MD, PhD, FCCM², Juraj Sprung, MD, PhD³, Daryl J Kor, MD³, Bala Subramaniam, MD⁴, Ricardo Martinez Ruiz, MD⁵, Jae-Woo Lee⁶, William G Henderson⁷, Angela Moss, MS¹, Niten Mehdiratta⁷, Megan Colwell⁸, Karsten Bartels, MD¹, Kerstin Kolodzie⁶, Jadelis Giquel⁵, Marcos Francisco Vidal Melo⁸, Ana Fernandez-Bustamante, MD, PhD^1
1University of Colorado School of Medicine, Aurora, Colorado, ²Brigham and Women’s Hospital, Boston, Massachusetts, ³Mayo Clinic, Rochester, Minnesota, ⁴Beth Israel Deaconess Medical Center, Boston, Massachusetts, ⁵University of Miami, Palmetto Bay, Florida, ⁶University of California, San Francisco, San Francisco, California, ⁷Vanderbilt University Medical Center, Nashville, Tennessee, ⁸Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

Patient Safety
PS 49 (1048): Intraoperative Neuromuscular Blocking Agent Administration and Hospital Readmission
Tharusan Thevathasan¹, Shirley Shih, MD, MS², Kyan C. Safavi, MD, MBA¹, David L Berger, MD¹, Sara M Burns, MS¹, Matthias Eikermann, MD, PhD¹, Jeffrey C. Schneider, MD^2
1Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, ²Massachusetts General Hospital, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts

Finalists — Clinical Research

Airway Management
AM 39 (1350) Predictors of Difficult Intubation: A Prospective Study of 1351 Patients
Tiffany Moon, MD, Yuri Volnov, BS, Michael X. Gonzales, MS, Agnes Kim, BA, Charles S. Koshy, MD, Abu Minhajuddin, PhD, Babatunde Ogunnaike, MD
University of Texas Southwestern, Dallas, Texas

Cardiovascular Anesthesiology
CA 21 (1477) Plasma Free Hemoglobin, Oxidative Damage, and Acute Kidney Injury in Cardiac Surgery
Marcos G. Lopez, MD, MS, Mias Pretorius, Frederic T. Billings, MD, Mac
Vanderbilt University Medical Center, Nashville, Tennessee

Critical Care
CC 54 (1276) Motoric Subtype of Delirium and Global Cognition after Critical Illness
Christina J. Hayhurst, MD, Mayur B. Patel, MD, MPH, FACS, Jim Jackson, PsyD, Annachiara Marra, MD, Jennifer L. Thompson, MPH, Rameela Chandrasekhar, PhD, Christopher Hughes, MD
Vanderbilt University Medical Center, Nashville, Tennessee

Critical Care
CC 55 (2254) Persistence of Newly Acquired Epigenetic Changes in PU.1 in Sepsis Survivors
Krzysztof Laudanski, MD, PhD¹, Mateusz Zawadka, MD², Jacek Polosak, PhD³, Monika Puzianowska-Kuz´nicka, MD, PhD^3
1University of Pennsylvania, Philadelphia, Pennsylvania, ²Warsaw Medical University, Warsaw, Poland, ³Mossakowski Research Center, PAS, Warsaw, Poland

Liver
L 20 (1159) Metabolomic Profiling of Post-Reperfusion Coagulopathy in Liver Transplantation
Nathan Clendenen, MD, Kirk Hansen, PhD, Angelo D’Alessandro, PhD, Nathaen Weitzel, MD
University of Colorado, Aurora, Colorado

Perioperative Anesthesia
PA 34 (1465) Impact of Intraoperative Hyperglycemia on Postoperative Outcomes
Nirav Shah, MD, Sachin Kheterpal, MD, MBA, Aleda Thompson, MS, Sathishkumar Subramaniam, MD
University of Michigan, Ann Arbor, Michigan

Regional Anesthesia
RA 51 (1869) Ultrasonographic Assessment of Topographic Anatomy of Brachial Plexus at Infraclavicular Fossa
Ajeet Kumar, MD, Abhyuday Kumar, MD
All India Institute of Medical Sciences, New Delhi, India

Finalists — Basic Science Research

Anesthetic Pharmacology
AP 4 (1334) Isoflurane Effects on Pro-Inflammatory Interleukin-23 Activity in Mice
Lindsay Stollings, MD¹, Li-Jie Jia, MD², Pei Tang, PhD³, Huanyu Dou, MD³, Binfeng Lu, PhD1, Yan Xu, PhD^1
1University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, ³Texas Tech University Health Sciences Center, El Paso, TX

Liver
L 24 (1910) Sevoflurane Provides Protection in Hepatic Ischemia-Reperfusion Injury by Decreasing ROS-Induced Apoptosis in Hepatocytes
Martin Schlapfer, MD, MSc¹, Birgit Roth Z’Graggen, PhD², Erik Schadde, MD², Beatrice Beck-Schimmer, MD^1
1University Hospital Zurich, Zurich, Switzerland, ²University of Zurich, Zurich, Switzerland

Neuroscience in Anesthesiology and Perioperative Medicine
NR 33 (1635) Effects of Metabotropic Glutamate Receptor Blockers on Ketamine and Dexmedetomidine Induced Neonatal Brain Injury in a Rat Model
Tinatin Chabrashvili, MD, PhD¹, James Marchand, PhD², Jesus Azocar, BS³, Antonella Pirone, PhD⁴, Roman Schumann, MD¹, Ruben Azocar, MD, FCCM^1
1Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, ²University of Michigan at Ann Arbor, Ann Arbor, Michigan, ³Tufts Medical Center, Boston, Massachusetts, ⁴Tufts University School of Medicine, Boston, Massachusetts

Neuroscience in Anesthesiology and Perioperative Medicine
NR 36 (1584) Deep Hypothermic Circulatory Arrest Does Not Induce RNA-Binding Motif Protein 3 (RBM3) in Hippocampus in Adult Rats
Tomas Drabek, MD, PhD¹, Elizabeth Snajdar, OMS², Jason P Stezoski1, Kyle S Simqu³, Patrick M Kochanek, MD¹, Travis C. Jackson, PhD^1
1University of Pittsburgh, Pittsburgh, Pennsylvania, ²Ohio University, Dublin, OH, ³Kent State University, Kent, Ohio

Pain Mechanisms
PME 65 (1500) The Chronic Effects of Nicotine on Pain Sensitivities and on Neuropathic Pain in Adult Rats
Angelica M. Jaramillo, MD, Jeimy Alfonso, Yiliam F. Rodriguez Blanco, MD, Keith A. Candiotti, Yanping Zhang, PhD
University of Miami, Miami, Florida

Pain Mechanisms
PME 66 (1598) Yokukansan, Japanese Herbal Medicine, Suppresses the Substance P-induced Production of IL-6 and IL-8 by Human U373MG Glioblastoma/Astrocytoma Cells
Keisuke Yamaguchi, MD, MBA
Juntendo Tokyo Koto Geriatric Medical Center, Koto-ku, Tokyo, Japan

Pediatric Anesthesiology
PED 13 (1121) Mitochondrial cAMP-dependent Phosphorylation in the Developing Murine Brain
Yang Long, MD, Aili Wang, MD, Richard J. Levy, MD, FAAP
Columbia University, New York, New York

Finalists — Scholars

Medically Challenging Cases
MCC 1 (1312) Near-Miss Hyperkalemic Arrest During Orthotopic Liver Transplant
Eric Brown, MD, Hemant Joshi, MD, PhD, Jeffrey D. White, MD
University of Florida, Gainesville, Florida

Medically Challenging Cases
MCC 8 (1076) Anesthetic Management of a Pediatric Patient with Pelizaeus-Merzbacher Syndrome
Jacob Esquenazi, MD, Roshan Patel, MD
Montefiore Medical Center, Bronx, New York

Neuroscience in Anesthesiology and Perioperative Medicine
NR 31 (1282) Changes in the Propofol-Induced Frontal Electroencephalogram in Pediatric Patients with Autism Spectrum Disorder
Elisa Walsh, BS^1,2, Patrick L. Purdon, PhD^2,3,4, Emery N. Brown, MD, PhD^1,2,4
1Massachusetts General Hospital, Boston, Massachusetts, ²Harvard Medical School, Boston, Massachusetts, ³Massachusetts General Hospital, Charlestown, Massachusetts, ⁴Massachusetts Institute of Technology, Cambridge, Massachusetts

Patient Safety
PS 41 (2149) Intraoperative Handover: What Are We Missing?
Sophia Lane, MD, Marketa Gross, RN, Cristian Arzola, MD, Archana Malavade, MD, Zeev Friedman, MD
Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

Patient Safety
PS 68 (1549) Trends of Intraoperative Opioid and Non-Opioid Analgesic Use and Associated Postoperative Pain Scores at an Academic Tertiary Care Hospital over a Four-Year Period
Gregory A. Smith, MD, Marcel Durieux, MD, PhD, Bhiken Naik, MBBCh
University of Virginia, Charlottesville, VA

Pediatric Anesthesiology
PED 29 (1529) The Under Accounted for Role of Hypercarbia & Hypoxia in the Neonatal Rodent Models of Anesthesia-Related Developmental Delay
Ryan Lamm, BA, Kseniya Khmara, MD, Thomas F. Floyd, MD
Stony Brook University, Stony Brook, New York

Respiration
RES 73 (1930) Comparing the Effects of Laparoscopic and Open Abdominal Surgery on Postoperative Respiratory Complication, Readmission, Hospital Length of Stay and Costs: A Propensity Score-based Analysis
Maira I. Rudolph, Vicki Sein, MD, Sara M. Burns, MS, Megan B. Zhang, BA, Thomas H. Shin, PhD, Matthias Eikermann, MD, PhD
Massachusetts General Hospital, Boston, Massachusetts