2008 Clinical Scholar Research Award

Konrad Meissner, MD
Instructor, Department of Anesthesiology
Washington University in St. Louis
St. Louis, Missouri

Dr. Meissner’s Research

Role of P-glycoprotein in Cerebral Morphine Disposition and Analgesia.

Related Publications

Cyclosporine-inhibitable Cerebral Drug Transport Does Not Influence Clinical Methadone Pharmacodynamics.
Meissner K, Blood J, Francis AM, Yermolenka V, Kharasch ED.

Interindividual variability and drug interaction studies suggest that blood-brain barrier drug transporters mediate human methadone brain biodistribution. In vitro and animal studies suggest that methadone is a substrate for the efflux transporter P-glycoprotein, and that P-glycoprotein-mediated transport influences brain access…

Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics.
Meissner K, Avram MJ, Yermolenka V, Francis AM, Blood J, Kharasch ED.

The blood-brain barrier is richly populated by active influx and efflux transporters influencing brain drug concentrations. Morphine, a drug with delayed clinical onset, is a substrate for the efflux transporter P-glycoprotein…

Read Dr. Meissner’s recent publications and articles.

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The 2019 IARS Annual Meeting and International Science Symposium will be aligned with the Society of Critical Care Anesthesiologists (SOCCA) and Association of University Anesthesiologists (AUA) Annual Meetings, May 16 – May 20, 2019 at the Fairmont The Queen Elizabeth Hotel in Montreal, Quebec, Canada.

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