Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo. 12/7/22. Torchia JA. Science Advances.

Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo. 12/7/22. Torchia JA. Science Advances. These investigators report the development of recombinant soluble forms of the cell surface...

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial. 12/25/2022. Butler CC. Lancet.

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial. 12/25/2022. Butler CC. Lancet. Reviews prior to this study...

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution. 12/19/2022. Cao Y. Nature.

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution. 12/19/2022. Cao Y. Nature. Immune imprinting occurs when exposure to an original viral strain prevents our bodies from producing sufficient neutralizing antibodies (NAb) against diverse...

Diaphragm Muscle Weakness Might Explain Exertional Dyspnea Fifteen Months After Hospitalization for COVID-19. 1/3/23. Regmi B. Am J Respir Crit Care Med.

Diaphragm Muscle Weakness Might Explain Exertional Dyspnea Fifteen Months After Hospitalization for COVID-19. 1/3/23. Regmi B. Am J Respir Crit Care Med. The etiology of long COVID/Post-COVID Condition (PCC) remains an enigma. Recent studies consider multiple causes...

Two masks can be worse than one: N95 respirator failure caused by an overlying face mask. 12/20/22. Mueller JT. Infection Control & Hospital Epidemiology.

Two masks can be worse than one: N95 respirator failure caused by an overlying face mask. 12/20/22. Mueller JT. Infection Control & Hospital Epidemiology. Adding an external procedure mask in front of a filtering face-piece respirator (FFR), such as an N95, has...

Impact of SARS-CoV-2 variants on inpatient clinical outcome. 12/18/2022. Robinson ML. Clin Infect Dis.

Impact of SARS-CoV-2 variants on inpatient clinical outcome. 12/18/2022. Robinson ML. Clin Infect Dis. This study, from EHR and databases for 5 Johns Hopkins hospitals between 9/2020 and 5/2022, assesses approximately 4,500 patients hospitalized for COVID-19 grouped...