FARA Key Research Questions

Fundamental Neuroscience Unknowns

What is the mechanism of anesthesia?
What is consciousness?
What is sleep?
What is pain?
What is the trigger between acute and chronic pain?
Fundamental mechanisms of drug action during anesthesia/surgery
How do we safely anesthetize kids?
How do we safely anesthetize adults?
What are the long-term effects of surgery?
What is the mechanism underlying perioperative cognitive dysfunction?
What are the mechanisms and interventions possible for postoperative delirium?
Can specific anesthesia techniques influence (positive influence or protect from) long-term sequelae of surgery?

Immune and Metabolic Consequences of Trauma, Surgery and Critical Care

What is the role of mitochondrial dysfunction in perioperative outcomes?
What is the best way to control/manage robust inflammatory response to surgery?
What non-traditional adjuvants (botox/acupuncture/non-opioids) are effective and should be included in practice?
What are the mechanisms underlying organ dysfunction in trauma/burn and intervention targets?
What are key mechanisms for prevention/treatment of sepsis?
What is the best way to monitor brain function in an anesthetized patient?
What are the long-term risks to having surgery and anesthesia (early CAD)?
What is on the horizon for coagulation biology and where would this be helpful in the OR?
What is the best strategy for perioperative transfusions?
What is the best way to assess adequate perfusion during anesthesia?
What are new ways of understanding fluid biology during surgery? (e.g. does “third space” really exist under stress of surgery with infusion therapy?)

How can anesthesia revolutionize rapid response teams to enhance patient safety?
What system changes need to be made to appropriately include postoperative analgesia with intraoperative anesthesia (regional/general combo efficiency)?
What practices in the OR truly affect ICU course, positive or negative?
What is the role of regional anesthesia (risks/benefits) in OR anesthesia and postoperative pain management?
How do we enhance perioperative patient safety?
Do we have the best preoperative risk assessment?
What is the safest way to manage out of OR sedation?
How do we risk assess patients for non-CAD illnesses (thrombosis, SIRS, etc)?
How can we most effectively translate knowledge/science to evidence-based anesthesia practice?
What health disparities exist in anesthesia and how can we overcome such barriers in patient care?
What is the best way to assess patient outcome after surgery/anesthesia?
What are the best, and most innovative, ways of educating MD anesthesiologists for future practice in the world of health care teams?

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San Francisco, CA 94105

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