2008 Clinical Scholar Research Award
During Award Period
University Medical Center Freiburg
Dr. Schmidt’s Research
Organ Protection by Hepatic Heme Oxygenase-1 Up-Regulation Through Volatile Anesthetics in Humans
Hepatic ischemia and reperfusion (I/R) injury during liver surgery is still the main cause of postoperative liver failure and the subsequent rise of mortality in these patients. During the last few years, a multitude of underlying mechanisms have been extensively characterized and many different protective approaches have been evaluated…
Hepatic steatosis prevents heme oxygenase-1 induction by isoflurane in the rat liver.
Stoll P, Schwer CI, Goebel U, Buerkle H, Hoetzel A, Schmidt R.
To characterize the inductive effects of isoflurane (ISO) on hepatic heme oxygenase-1 (HO-1) in an animal model of hepatic steatosis. Lean (LEAN) and obese (FAT) Zucker rats were randomized into 4 groups: 1: LEAN + pentobarbital sodium (PEN); 2: LEAN + ISO; 3: FAT + PEN; 4: FAT + ISO…
Read Dr. Schmidt’s recent publications and articles.
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