Initiative for Multicenter Pragmatic Anesthesiology Clinical Trials (IMPACT)

This award was established by leaders of academic anesthesiology organizations that recognized there was a need to conduct large pragmatic trials in order to answer important questions in anesthesiology-related research. Although there are several successful anesthesiology clinical trial networks around the world, until now, one did not exist in the United States. In an initial attempt to address this important opportunity, a consortium of academic anesthesiology organizations launched an initiative in 2018 to stimulate pragmatic research in the U.S. in collaboration with our colleagues in Canada, the Canadian Perioperative Anesthesia Clinical Trials Group (PACT), and elsewhere. This effort was conceptualized and endorsed by a few key organizations, which have as a common goal the advancement of knowledge in anesthesiology and the enhancement of care in perioperative medicine, critical care, pain management, and peri- and post-partum care. These organizations included:

These organizations have joined together and established a program to support the development of proposals for pragmatic clinical trials by anesthesiology investigators for submission to external funding sources, such as the NIH. By working together, we believe that we can improve the quality of the proposals and increase the prospects of securing funding. The process includes an opportunity for input and advice from knowledgeable sources, along with a $15,000 grant to support the development of the final proposal.

The process:  The grant cycle opens in October, with Letters of Intent accepted through late November.  The Letter of Intent should outline the personnel, institutions and specific aims of a pragmatic clinical trial in perioperative medicine, see guidelines.  The LOI’s are reviewed by a panel of Anesthesiology experts.  From the pool of LOI’s, six applicants are chosen to write a full proposal.  The six full proposals undergo an additional expert review and three finalists are chosen to receive the $15,000 award.  The award is meant to support the three finalists with the development costs of writing a larger grant, to help increase the likelihood of a major grant award.

Note: The 2019 IMPACT Application period is now closed. The next IMPACT grant cycle will begin in October. Keep an eye on our website for more details.

Past Recipients

Karim Ladha, MD
The Comparison of Analgesic Regimen Effectiveness for Surgery (CARES) Trial
Assistant Professor & Staff Anesthesiologist
Department of Anesthesia and Pain Medicine
University Health Network, Toronto General Hospital

David Mazer, MD
TRICS IV-Restrictive versus Liberal Transfusion in Younger Patients Undergoing Cardiac Surgery
Associate Scientist & Professor
St Michael’s Hospital, Toronto

Robert Schonberger, MD, MHS
Improving population health via the surgical encounter: Targeting underuse of statins
Associate Professor
Yale University – School of Medicine

Michael Aziz, MD
Optimized Opioid Management or Usual Treatment to Reduce Persistent Opioid Use Following Surgery (OPT-OUT).
Professor
Anesthesiology & Preoperative Medicine
Oregon Health & Science University

Randall Blank, MD, PhD
Individualized Intraoperative Protective Ventilation using an Open Lung Approach with Driving Pressure Limitation.
Associate Professor of Anesthesiology
Chief, Thoracic Anesthesia
Department of Anesthesiology
University of Virginia Health System

Frederic T. (Josh) Billings IV, MD, MSc
Intraoperative Normoxia versus Hyperoxia during Maintenance Anesthesia to Reduce Postoperative Complications.
Associate Professor of Anesthesiology and Medicine
Co-director, BH Robbins Scholars Physician-Scientist Development Program
Vanderbilt University

2019

Karim Ladha, MD
The Comparison of Analgesic Regimen Effectiveness for Surgery (CARES) Trial
Assistant Professor & Staff Anesthesiologist
Department of Anesthesia and Pain Medicine
University Health Network, Toronto General Hospital

David Mazer, MD
TRICS IV-Restrictive versus Liberal Transfusion in Younger Patients Undergoing Cardiac Surgery
Associate Scientist & Professor
St Michael’s Hospital, Toronto

Robert Schonberger, MD, MHS
Improving population health via the surgical encounter: Targeting underuse of statins
Associate Professor
Yale University – School of Medicine

2018

Michael Aziz, MD
Optimized Opioid Management or Usual Treatment to Reduce Persistent Opioid Use Following Surgery (OPT-OUT).
Professor
Anesthesiology & Preoperative Medicine
Oregon Health & Science University

Randall Blank, MD, PhD
Individualized Intraoperative Protective Ventilation using an Open Lung Approach with Driving Pressure Limitation.
Associate Professor of Anesthesiology
Chief, Thoracic Anesthesia
Department of Anesthesiology
University of Virginia Health System

Frederic T. (Josh) Billings IV, MD, MSc
Intraoperative Normoxia versus Hyperoxia during Maintenance Anesthesia to Reduce Postoperative Complications.
Associate Professor of Anesthesiology and Medicine
Co-director, BH Robbins Scholars Physician-Scientist Development Program
Vanderbilt University

Encourage, stimulate, and fund ongoing anesthesia-related research projects that will enhance and advance the specialty, and to disseminate current, state-of-the-art, basic and clinical research data in all areas of clinical anesthesia, including perioperative medicine, critical care, and pain management. The IARS is focused solely on the advancement and support of education and scientific research related to anesthesiology.
A&A
OpenAnesthesia
A&A Case Reports
SmartTots

2019 Annual Meeting

The 2019 IARS Annual Meeting and International Science Symposium will be aligned with the Society of Critical Care Anesthesiologists (SOCCA) and Association of University Anesthesiologists (AUA) Annual Meetings, May 16 – May 20, 2019 at the Fairmont The Queen Elizabeth Hotel in Montreal, Quebec, Canada.

Support IARS

The IARS contributes more than $1 million each year to fund important anesthesia research. Your donation will help support innovative and forward-thinking anesthesia research and education initiatives, all of which are designed to benefit patient care. You can feel good knowing that 100% of your donation is directly allocated to research.